PDRN (polydeoxyribonucleotide, listed as Sodium DNA) is a nucleotide-based active used in skincare to support a hydrated, recovered, rejuvenated-looking complexion.
- INCI name
- Sodium DNA
- Also called
- Polydeoxyribonucleotide, Sodium DNA, Salmon DNA
- Category
- Nucleotide
- In these formulas
- Pinky Promise, The Serum Trio
What is PDRN?
- PDRN is a mixture of DNA-derived nucleotide fragments, the same family of actives behind the 'salmon DNA' facials popularised in Korean clinics.
- In topical formulas it behaves as a hydrating, barrier-supporting active rather than an exfoliant, so it suits reactive skin.
- Glo Key pairs PDRN with niacinamide, ectoin, glutathione and a peptide complex in Pinky Promise.
What does the research cover?
- Nucleotide actives are studied for skin-recovery and hydration endpoints, and are widely used in post-procedure aftercare protocols.
- Cosmetic PDRN formulas are generally well tolerated at daily frequency, including on sensitised skin.
- Visible smoothness and plumpness usually read first, within 2–4 weeks.
Who is PDRN best for?
- Dull, dehydrated skin that looks tired rather than oily
- Skin recovering from a hot summer, wind, or a course of strong actives
- Anyone who wants results without the sting of acids or retinoids
How do you use PDRN?
- 3–4 drops on clean, dry skin morning and night, pressed into face and neck.
- Layer it under moisturiser; it plays well with almost everything.
- If you also use strong exfoliating acids, introduce PDRN gradually.
What does it pair with?
- Niacinamide
- GHK-Cu
- Ectoin
- Sodium Hyaluronate
- SNAP-8
What should you avoid layering with it?
- Stacking with several high-strength acids in one routine while your barrier is compromised.
PDRN questions
What does PDRN do for skin?
It works as a hydrating, recovery-focused active — skin typically looks plumper, calmer and more even in tone with consistent use.
Can I use PDRN every day?
Yes. Pinky Promise is formulated for twice-daily use, including on sensitive skin.
Can you use PDRN and copper peptides together?
Yes — PDRN layers comfortably with GHK-Cu. Apply the thinner serum first and let it absorb.
